Glycolysis is an important metabolic pathway for most organisms, including protozoan parasites. Many of these primitive eukaryotes have streamlined their metabolism, favoring glycolysis for generating ATP in the glucose-rich environments in which they reside. Therefore, the enzymes involved in hexose metabolism could prove to be attractive targets for therapeutic development.
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- Features of protozoans.
This hypothesis is supported by a number of chemical and genetic validation studies. Additionally, the peculiar biochemistry of many of the components, along with limited protein sequence identity emphasizes the likelihood of developing compounds that selectively inhibit the parasite enzymes.
Novel biochemical pathways in parasitic protozoa.
While the proteins from some species have been interrogated to the point that well-defined lead compounds have been identified with activities against both enzyme and parasite growth, progress in other systems has to date been limited. Abstract: Glycolysis is an important metabolic pathway for most organisms, including protozoan parasites. Harris, W. Mitchell and J. Journal Name: Current Medicinal Chemistry. Volume 21 , Issue 15 , The selection first offers information on the biochemistry of Protozoa and phytoflagellates, including sexuality in Chlamydomonas, growth factors and chemical asepsis, descriptive chemistry and phylogenetic relationships, evolutionary aspects of photosynthesis, nutrition and biochemistry of Protozoa, and the biochemical evolution of Protozoa.
The text then ponders on the nutrition of parasitic flagellates and metabolism of Trypanosomidae and Bodonidae. The publication takes a look at the nutrition of parasitic amebae, biochemistry of Plasmodium and the influence of antimalarials, and the biochemistry of ciliates in pure culture.
Molecular Biology of Parasitic Protozoa
Topics include carbon metabolism and respiration, nitrogen metabolism, antimalarial compounds and their influence on the metabolism of malarial parasites, metabolism of malarial parasites, and nutrition of the dysentery ameba, Entamoeba histolytica. The selection is a valuable reference for cytologists, geneticists, and pathologists interested in the biochemistry and physiology of protozoa. We are always looking for ways to improve customer experience on Elsevier.
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